Use of Paracetamol
Paracetamol is a drug of choice for reducing fever. However, there has been a lack of research on its antipyretic properties, particularly in adults. The most recent review on paracetamol and management of fever in the general practice (2008) argued that its benefits are unclear. Additionally, when taken for the common cold paracetamol may relieve stuffed or runny nose but not other cold symptoms such as sore throat, malaise, sneezing and cough; this data, however, is of low quality.
Classical methods of paracetamol
The classical methods for the production of paracetamol involve the acetylation of 4-aminophenol with acetic anhydride as the last step. They differ in how 4-aminophenol is prepared. In one method, nitration of phenol with nitric acid affords 4-nitrophenol, which is reduced to 4-aminophenol by hydrogenation over Raney nickel. In another method, nitrobenzene is reduced electrolytically giving 4-aminophenol directly. Additionally, 4-nitrophenol can be selectively reduced by Tin(II) Chloride in absolute ethanol or ethyl acetate to produce a 91% yield of 4-aminophenol.
MULEI specialize in the production of acetaminophen and other analgesic chemicals like phenacetin, benzocaine, lidocaine, procaine etc.
Is ibuprofen and paracetamol same?
Paracetamol and ibuprofen are different classes of painkillers and are metabolised in different organs within the body. Paracetamol works similarly to ibuprofen by blocking the production of prostaglandins and COX enzymes in the body – chemicals that promote pain, inflammation and fever.
What is paracetamol is used for?
Paracetamol is a commonly used medicine that can help treat pain and reduce a high temperature (fever). It’s typically used to relieve mild or moderate pain, such as headaches, toothache or sprains, and reduce fevers caused by illnesses such as colds and flu.
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